Combating Ivermectin Resistance: One of the ongoing challenges in the use of Ivermectin is the emergence of resistance in certain parasitic organisms. Prolonged and widespread use of the drug can lead to resistance, making treatment less effective over time. This underscores the importance of responsible use, proper dosing, and the development of alternative treatments to address parasitic infections, particularly in regions where resistance has become a concern. stromectol over the counter.